pentobarbital will minimize the extent or impact of pitolisant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Pitolisant exposure is lessened by fifty% if coadministered with sturdy CYP3A4 inducers.pentobarbital will decrease the level or impact of diclofenac by affecting hepatic enzyme CYP2C9/10 metabol